Distributed Informatics Sub-Centre (Sub- DIC)

Recognng the importance of Bioinformatics and Computational Biology at the intersection of various disciplines of Bio-Sciences, the Department of Biotechnology (DBT) supported one of the largest nation-wide Biotechnology Information System Network (BTISNet) to accelerate R&D in biotechnology sector. At present, 5 Centres of Excellence (CoE), 12 Distributed Information Centres (DICs), 43 Distributed Information Sub-Centres (DISCs) and 88 Bioinformatics Infrastructure Facilities (BIFs) are being supported all over the country (http://btisnet.gov.in)

 

About DISC

The centre was established in 1995 with the major emphasis and training and research in the field of bioinformatics. The centre has well established facilities for carrying out database search, analysis of biological data and performing in silico work. The centre is extensively involved in structural bioinformatics, molecular modeling and drug designing.  These in silico approaches are being utilized in order to provide necessary insights into understanding various biological processes in plants and human diseases. Specific areas where significant leads have been obtained by the center involve: 

 

Objective

  • To act as a node of the national bioinformation network designed to bridge the inter-disciplinary gaps on biotechnology information and establish link among scientists in organizations involved in R&D and industries
  • To build information resources, analyse data, prepare database on Biotechnology and develop the relevant information handling tools and techniques
  • To continuously assess information requirements and to provide information and computer support services to the national community of users
  • To coordinate efforts to access world-wide Biotechnology information from international resources of Biotechnology from international resources of Biotechnology information

 

Workshops

Sr.no. Title of Workshop /Year No. of Participants
1. Workshop on “Latest Trends in Bioinformatics” March 4-6, 1998 16
2. Workshop on “Use of Internet & Patenting in   Biosciences  Research”  March 23-24, 1999 14
3. Workshop on “Role of Networking in Scientific  Information  Processing” October 27-  28, 1999. 10
4. Workshop on “Internet and Web Designing” October 5-6, 2000 15
5. Workshop on “Tools for Data Mining” October 7-  8, 2003. 17
6. Workshop on “Tools of Bioinformatics” March 3-4, 2005 21
7. Workshop on “Advances in Bioinformatics” February 23rd& 24th , 2006 18
8. Workshop on “Bioinformatics : Conceptualizing Biology in terms of Molecules” February 22rd& 23rd  , 2007 16
9. Workshop on “Structural Bioinformatics towards Drug Design” March 21st -22nd , 2008. 16
10. Workshop on “Bioinformatics tools in Biological Research” March 19th -20th , 2010 17
11. Workshop on “Bioinformatics Applications in Genomics and Proteomics” November 5th -6th, 2011 18
12. Workshop on “Structural Bioinformatics” February  21st& 22rd , 2013 21
13 Workshop on “ Recent Trends in Bioinformatics” on 07th -08th March, 2017 28
14 International meet & Golden Jubilee workshop on “Basic and Translational Research in Health Sciences” on 20th – 22nd February, 2019 50

Facilities

Infrastructure

  • Computer labs = 3
  • Multimedia projectors = 6
  • Computer Systems including servers = 94
  • Podium System = 3
  • Workstatiion = 1

 

List of Softwares

  • Discovery Studio
  • Mendeley
  • Visual Studio 6.0
  • Macromedia Studio MX-2004
  • Lasergene-5 Sequence Analysis software
  • Exome Version 1.3
  • Exome Blast Version 1.0
  • Oracle 10g Standard Edition one five user with multimedia kit
  • Exome Tm Version 1.0 18 user = 1X18 licence
  • Hyperchem
  • Endnote
  • ChemDraw
  • Autodock
  • Modeller
  • Cytoscape

 

Other resources

  • Borland Turbo C++ Suite
  • Sigma Plot 2001 (V-7.1)
  • Grafit – Version 4 (Erithacus Software)
  • Adobe Page Maker 6.5
  • Adobe Illustrator 9.0
  • Adobe Photosho
  • Corel draw 12
  • Minitab 13
  • Aobe Acrobat

 

List of Databases:

  • Medline (1966-2007)
  • Agricola (1970-2007)
  • Agris (1975-2007)
  • Life Science Collection (1982-1998)
  • Biotechnology Abstracts (1982-1997)
  • Food Science & Technology    (1990-1998)

 

Publications: Key Pubications in Bioinformatics:

Sr. No. List of publications Impact Factor
1. K., Snedden W.A.,   Kapoor K.,   Pareek A. and   Singh Kaur G., Singh S., Singh H.,  Chawla M., Dutta T., Kaur H., Bender Prabhjeet* (2015). Characterization of peptidyl-prolyl cis-transisomerase- and calmodulin-binding activity of a cytosolic Arabidopsis thaliana cyclophilin AtCyp19-3. Plos One, 10.8:e0136692.   3.54
2. Kaur, G., Sharma, A., Guruprasad, K., &Pati, P.K. (2014). Versatile roles of plant NADPH oxidases and emerging concepts. Biotechnology advances,32(3), 551-563. doi.org/10.1016/j. biotechadv.2014.02.002 11.452
3. Kaur, G., &Pati, P.K. (2016). Analysis of cis-acting regulatory elements of Respiratory burst oxidase homolog (Rboh) gene families in Arabidopsis and rice provides clues for their diverse functions. Computational biology and chemistry62, 104-118. doi.org/10.1016/j.compbiolchem.4.002 1.412
4. Singh, V., Singh, B., Joshi, R., Jaju, P., &Pati, P.K. (2017). Changes in the leaf proteome profile of Withania somnifera (L.) Dunal in response to Alternaria alternata infection. PloS One, 12(6), e0178924.doi.org/10.1371/journal.pone.0178924 2.766
5. Varinder Singh, Sunil C. Kaul, Renu Wadhwa and Pratap Kumar Pati (2015) Evaluation and selection of candidate reference genes for normalization of quantitative RT-PCR in Withania somnifera (L.) Dunal PLoS ONE  10(3): e0118860. doi:10.1371/journal.pone. 011886. 3.54
6. Gurpreet Kaur and Pratap Kumar Pati (2017) In silico physicochemical characterization and topology analysis of Respiratory burst oxidase homolog (Rboh) proteins form Arabidopsis and rice. Interdisciplinary Sciences-Computational Life Sciences. 0.753
7. Loers G, Saini V, Mishra B, Papastefanaki F, Lutz D, Chaudhury S, Ripoll DR,Wallqvist A, Gul S, Schachner M, Kaur G (2014). Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture. J Neurochem. Jan;128(1):88-100. doi: 10.1111/jnc.12408. 4.24
8. Jabalia, N., P.C. Mishra, and Chaudhary N., “Applications,Challenges and Future Prospects of Proteases: An Overview”,Journal of Agroecology and Natural Resource Management,2014, pp. 179-183. 4.23
9. Neetu Jabalia1*, Hina Bansal2, P.C. Mishra and Nidhee Chaudhary”In-silico Comparative analysis of Papain Family Cysteine Protease using Computational Tools and Servers”, International Journal of Basic and Applied Biology [IJBAB] (Print ISSN: 2349 – 5820; Online ISSN: 2349 – 5839 Online ISSN: 2349-2539, Volume 2, Number 5; April-June, 2015, pp. 310-314. 3.90
10. Gurpreet Kaur, Kunchur Guruprasad, Brenda R.S. Temple, David G. Shirvanyants,Nikolay V. Dokholyanand Pratap Kumar Pati (2017) Structural complexity and functional diversity of plant NADPH Oxidases. Amino Acids. DOI: 10.1007/s00726-017-2491-5. 3.17
11. Kumar V, Kaur J, Singh AP, Singh V, Bisht A, Panda JJ, P.C. Mishra, Hora R. PHISTc protein family members localize to different subcellular organelles and bind Plasmodium falciparum major virulence factor PfEMP-1. FEBS J. 2017 Nov 20. doi: 10.1111/febs.14340. [Epub ahead of print] PubMed PMID: 29155505 4.2
12. J Kaur, V Kumar, AP Singh, V Singh, A Bisht, T Dube, JJ Panda, A Behl, P. C Mishra, R Hora (2018) Plasmodium falciparum protein ‘PfJ23’ hosts distinct binding sites for major virulence factor ‘PfEMP1’ and Maurer’s cleft marker ‘PfSBP1’. Pathogens and Disease, 76(9): 1-13. 2.337
13 A Behl, V Kumar, A Bisht, JJ Panda, R Hora, P. C Mishra (2019) Cholesterol bound Plasmodium falciparum co-chaperone ‘PFA0660w’ complexes with major virulence factor ‘PfEMP1’ via chaperone ‘PfHsp70-x’. Scientific Report, 9(1):2664-2681 4.122
14. V Kumar, A Behl, P Kapoor, B Nayak, G Singh, AP Singh, S Mishra, TS Kang, P. C Mishra, R Hora (2019) Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipids with cytoskeletal element ‘actin’ and its associated motor ‘myosin’. International Journal of Biological Macromolecules, 126, 673-684. 3.909

Awards

  • Incentive Awards for Publications-2014 for getting fourth Position in the category of (Sub-DIC).
  • Incentive Awards for Publications-2015 for publishing the best paper entitled “Versatile roles of plant NADPH oxidases and emerging concepts” authored by Gurpreet Kaur, Ashutosh Sharma, Kunchur Guruprasad and Pratap Kumar Pati in the journal Biotechnology Advances., 2014, 32,551-563 among all the SubDICs.
  • Incentive Awards for Publications-2015 for getting third Position in the category of (Sub-DIC).
  • Incentive Awards for Publications-2016 for getting third Position in the category of (Sub-DIC).